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Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humans

โœ Scribed by Fisher, R.L.; Sanuik, J.T.; Nau, H.; Gandolfi, A.J.; Brendel, K.

Book ID
122078508
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
654 KB
Volume
8
Category
Article
ISSN
0887-2333

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โœ G. Richard Granneman; Shyh-Ing Wang; James W. Kesterson; Joseph M. Machinist ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 685 KB

The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch