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Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models

✍ Scribed by Anna V. Maslennikova; Anna G. Orlova; German Yu. Golubiatnikov; Vladislav A. Kamensky; Natalia M. Shakhova; Aleksey A. Babaev; Ludmila B. Snopova; Irina P. Ivanova; Vladimir I. Plekhanov; Tatyana I. Prianikova; Ilya V. Turchin

Book ID
102871429
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
881 KB
Volume
3
Category
Article
ISSN
1864-063X

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✦ Synopsis

Abstract

The capabilities of diffuse optical spectroscopy for noninvasive assessing of oxygen status in experimental tumors have been demonstrated. Specific features of the distribution of total hemoglobin, oxygenated hemoglobin, deoxygenated hemoglobin, and blood‐oxygen saturation were shown on two tumor models having different histological structure and functional characteristics. The results obtained by the optical technique were verified by immunohistochemical study of tissue samples marked with exogenous marker of hypoxia – pimonidazole. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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