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Comparative study of the sensitivity of virgin and pregnant rats to methylmercury

✍ Scribed by Laszlo Magos; George C. Peristianis; Thomas W. Clarkson; Roger T. Snowden; Muhammed A. Majeed

Book ID
104742248
Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
450 KB
Volume
43
Category
Article
ISSN
0340-5761

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✦ Synopsis

Pregnant and virgin female rats were dosed by gastric lavage 10 times or 5 times with 5 mg/kg mercury as methylmercury. Treatment of pregnant animals started on day 3 of gestation and ended on day 14 of gestation with two days break between the 5th and the 6th doses. In Group B, treatment lasted from day 10 to day 14 of gestation. Pregnant and virgin rats responded identically to methylmercury in terms of body weight changes, coordination disorders, and cerebellar histological changes. Furthermore, the brain, liver and kidney concentrations and the rates of methylmercury elimination in the post-treatment period were identical. Thus the resuits indicate no difference in sensitivity of pregnant versus non-pregnant animals.

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## Abstract As the two major glial cell types in the brain, astrocytes and microglia play pivotal but different roles in maintaining optimal brain function. Although both cell types have been implicated as major targets of methylmercury (MeHg), their sensitivities and adaptive responses to this met