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Comparative Study of the Regioselectivity and Reaction Media for the Synthesis of 1- tert -Butyl-3(5)-trifluoromethyl-1 H -pyrazoles

✍ Scribed by Martins, Marcos A. P.; Marzari, Mara R. B.; Frizzo, Clarissa P.; Zanatta, Marcileia; Buriol, Lilian; Andrade, Valquiria P.; Zanatta, Nilo; Bonacorso, Helio G.


Book ID
118234420
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
446 KB
Volume
2012
Category
Article
ISSN
1434-193X

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This study describes, firstly, the synthesis of a new precursor, 4,6,6-trimethoxy-1,1,1-trifluorohex-3-en-2-one (1), from the trifluoroacetylation reaction of 1,1,3,3-tetramethoxybutane, in 65% yields. Afterwards, the reaction of 1 with two hydrazines (NH 2 NHR, where R = 2-furanoyl, C 6 F 5 ) led t