Comparative study of the kinetic behaviour of ciprofloxacin and ofloxacin in the isolated hindlimb of the rat
β Scribed by A. Sanchez; C.Casquero Dorado
- Book ID
- 117628681
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 154 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0928-0987
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## Abstract The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscleβ boneβ and skinβtissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administ
1. In acute experiments anesthetized rats were treated with a subthreshold dose of 204Tl+, given intravenously in order to study the elimination kinetics of Tl+. Thallium disappeared from whole blood by means of two different half-lives (5 and 196 min, respectively), whereas VDbeta amounted to 1400