Fifty episodes of bleeding from esophageal or gastric varices in 33 patients with cirrhosis were randomized to treatment with either intravenous terlipressin (2 mg initially and 1 mg every 4 hr for 24 hr together with bolus injection and continuous infusion of placebo) or with somatostatin (250 micr
Comparative Study of Terlipressin, Somatostatin and Octreotide in Acute Esophageal Variceal Bleed: A Prospective Randomized Study
β Scribed by CK Adarsh; KS Prasanna; H Devarbhavi; D Karanth; Mallikarjuna; B Girisha
- Book ID
- 117689657
- Publisher
- Elsevier
- Year
- 2011
- Tongue
- English
- Weight
- 45 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0973-6883
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We undertook a multicenter randomized trial to compare the efficacy of terlipressin combined with transdermal nitroglycerin and that of octreotide in the emergency control of acute variceal hemorrhage in cirrhosis. Over 16 mo, 87 patients with endoscopically proved active bleeding from esophageal or
Somatostatin and endoscopic sclerotherapy are widely used in the treatment of acute variceal bleeding. Although objective evidence does exist about the advantages of either treatment, data comparing both procedures are scarce. In order to compare the effectiveness and safety of somatostatin and scle
trials have shown that somatostatin (SMT) is as effective as sclerotherapy in the treatment of acute variceal bleeding and that the combination of both treatments is more effective than sclerotherapy alone. To assess whether the addition of sclerotherapy improves the efficacy of SMT alone, all patie