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Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types

✍ Scribed by C. Delescluse; N. Ledirac; G. de Sousa; M. Pralavorio; D. Botta-Fridlund; Y. Letreut; R. Rahmani


Book ID
117587892
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
597 KB
Volume
11
Category
Article
ISSN
0887-2333

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Effect of cell density and epidermal gro
✍ J Greuet; L Pichard; J C Ourlin; C Bonfils; J Domergue; P Le Treut; P Maurel πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 411 KB πŸ‘ 2 views

The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat