Comparative studies on the distribution of gold, copper and zinc in the livers and kidneys of rats and hamsters after treatment with sodium [195/Au]-aurothiomalate
✍ Scribed by Ewa M. Mogihricka; M. Webb
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 433 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Abstract
The distribution of gold, copper and zinc in the livers and kidneys of female rats and hamsters was determined after intraperitoneal injection of sodium [^195^Au]‐aurothiomalate. After five doses of sodium [^195^Au]‐aurothiomalate (1 mg Au(I) per kg body weight), the hepatic and renal concentrations of Au were greater in rats than in hamsters. In the former species, treatment with the Au(I)‐compound led to an increase in the Cu‐concentration of the kidney and to the synthesis of a (Cu, Au)‐metallothionein. In either species binding of Au to the hepatic metallothionein was insignificant. The renal (Cu, Au)‐metallothionein from the sodium [^195^Au]‐aurothiomalate‐treated rat appeared to be extremely heterogeneous and was resolved into at least four components on ion exchange chromatography.