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Comparative studies on the absorption of3H-thalidomide in rabbits and rats

✍ Scribed by Keller, George R. ;Blake, David A.


Book ID
112216187
Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
796 KB
Volume
4
Category
Article
ISSN
0040-3709

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The absorption and disposition of methotrexate (MTX) in the plasma, synovial fluid (SF), skin, and muscle tissue were studied following administration of a topical MTX gel in rabbits and rats. In rabbits, MTX concentrations in the plasma increased steadily toward the peak (5.9 +/- 2.8 ng mL-1) which