Comparative studies of the total flavonoids and anthracene derivatives contents of St. John's wort preparations

Gauging the clinical significance of P-g

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

✍ Bill J. Gurley; Ashley Swain; D. Keith Williams; Gary Barone; Sunil K. Battu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Abstract Concomitant administration of botanical supplements with drugs that are P‐glycoprotein (P‐gp) substrates may produce clinically significant herb‐drug interactions. This study evaluated the effects of St. John's wort and __Echinacea__ on the pharmacokinetics of digoxin, a recognized P‐gp