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Comparative studies of Nsc and Fmoc as Nα-protecting groups for SPPS

✍ Scribed by Robert Ramage; Lu Jiang; Young-Deug Kim; Kevin Shaw; Jin-Li Park; Hack-Joo Kim

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
130 KB
Volume
5
Category
Article
ISSN
1075-2617

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✦ Synopsis

2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) is an alternative base-labile N h -protecting group to 9-fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc group exhibits moderate absorption at 380 nm which is excellent for real-time monitoring of the deprotection process. It also decreases the rearrangement of X-Asp, which can be a serious problem in SPPS.

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