Comparative studies of cadmium and mercury accumulation by LLC-PK1, cells: effects of pH on uptake and efflux
β Scribed by Tetsuya Endo; Osamu Kimura; Masakatsu Sakata
- Book ID
- 118412239
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 624 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0378-4274
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Cyclosporine A (CSA) is an effective immunosuppressant, but side effects such as renal toxicity can limit its therapeutic use. The current studies investigate the effects of lipoproteins on CSA-induced renal toxicity in the pig epithelial cell line LLC-PK 1 . Protein synthesis and tritiated CSA were
## Abstract The__V__~max~values (in nmol/mg protein/15 min) for AAAD in OK cells (0.94Β±0.08) were found to be significantly (__P__<0.01) lower than those observed in LLCβPK~1~cells (4.37Β±0.08). However, in both cell lines decarboxylation reaction was a saturable process with similar__K__~m~values (