Determination of bufuralol and its metab
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R. J. Francis; P. B. East; S. J. McLaren; J. Larman
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Article
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1976
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John Wiley and Sons
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English
β 375 KB
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A sensitive method for the simulataneous determination of bufuralol and its pharmacologically active metabolites in huamn plasma is described. The O-timethylsilyl,N-trifluoroacetyl derivatives are assayed by mass fragmentography. Sensitivity is 1 ng 76(-1) plasma for bufaralol and about 250 pg ml(-1