Binding of diazepam and desmethyldiazepa
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Marcia Divoll; David J. Greenblatt
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Article
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1981
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Springer
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English
โ 279 KB
The binding of diazepam (DZ) and its major metabolite desmethyldiazepam (DMDZ) to plasma protein was evaluated in a series of controlled in vitro studies using equilibrium dialysis. Free fraction (FF) of both drugs alone changed significantly with total plasma drug concentration, but the increased F