Comparative physiological disposition of two nitrofuran anti-microbial agents

✍ Scribed by J. P. Labaune; J. P. Moreau; R. Byrne

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 538 KB
• Volume: 7
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510070504

✦ Synopsis

The physiological disposition of two nitrofuran derivatives used as antimicrobial agents for the treatment of acute infectious diarrhoea was evaluated in humans and animals. Upon administration of a single oral dose (600mg) of nifurzide or nifuroxazide, no unchan ed parent drug was detected in human blood or urine. In rats cent of the dose of nifurzide and nifuroxazide, respectively, were excreted in urine over a 48-hour period. None of this radioactivity was present as unchanged drug, indicating that renal excretion of both drugs occurs as metabolites. In the faeces 20 per cent of the radioactivity recovered was associated with unchanged nifuroxazide as compared with 100 per cent for nifurzide. Whole body autoradiography using rats showed that after oral administration of I4C-nifurzide and "C-nifuroxazide, most of the radioactivity remained in the gastrointestinal lumen.

K ~Y WOKI)S

Nifurzidc Nifuroxazidc Infcctious diarrhoca

given "C-nifurzide and ' 5 '

C-nifuroxazide at a dose of lOmg kg-', 5 per cent and 17 per