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Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract

โœ Scribed by Yuan-Xiong Deng; Qun-Zhi Shi; Bo Chen; Xiao-Jie Zhang; Sheng-Zi Liu; Xi-Min Qiu


Book ID
118446104
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
561 KB
Volume
83
Category
Article
ISSN
0367-326X

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## Abstract The developmental toxicity of the three main metabolites of __N__โ€methylโ€2โ€pyrrolidone (NMP) was studied in Spragueโ€Dawley rats. Pregnant rats were given 5โ€hydroxyโ€__N__โ€methylโ€2โ€pyrrolidone (5โ€HNMP; 0, 250, 500, 750 or 1000 mg kg^โˆ’1^ day^โˆ’1^), __N__โ€methylsuccinimide (MSI; 0, 500, 750,