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Comparative Pharmacokinetic Assessment of Diclofenac Sodium Polycomplex Drug Delivery Systems Based on Eudragit Copolymers

โœ Scribed by Mustafin, R. I.; Semina, I. I.; Bukhovets, A. V.; Sitenkov, A. Yu.; Garipova, V. R.; Salakhova, A. R.; Kemenova, V. A.


Book ID
125367212
Publisher
Springer
Year
2014
Tongue
English
Weight
181 KB
Volume
48
Category
Article
ISSN
0091-150X

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## Abstract Rat pharmacokinetics and __in vivo__ disposition of a novel bisphosphonic prodrug of diclofenac (DICโ€BP), synthesized with the aim of osteotropic delivery of diclofenac, were determined at whole body, organ and cellular levels in a dose range 0.32โ€“10mg/kg. With an increase in injected d