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Comparative molecular modeling study of the three-dimensional structures of prostaglandin endoperoxide H2 synthase 1 and 2 (COX-1 and COX-2)

✍ Scribed by Marta Filizola; Juan J Perez; Albert Palomer; David Mauleón


Book ID
108488233
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
505 KB
Volume
15
Category
Article
ISSN
1093-3263

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A comparative study of the COX-1 and COX
✍ Shunzhou Wan; Peter V. Coveney 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 968 KB

## Abstract The monotopic proteins COX‐1 and ‐2 in dimeric form bound to lipid bilayer membranes are studied using molecular dynamics simulations within an aqueous environment. The 25‐ns simulations are performed for both isozymes with arachidonic acid bound in the cyclooxygenase sites. The interac