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Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography–tandem mass spectrometry

✍ Scribed by Lee, Sangkyu; Kim, In Sook; Kwak, Tae Hwan; Yoo, Hye Hyun


Book ID
120487045
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
891 KB
Volume
83
Category
Article
ISSN
0731-7085

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## Abstract Ganstigmine, a new acetylcholinesterase inhibitor, was incubated with rat liver microsomes and the resulting metabolites were identified by high‐performance liquid chromatographic/mass spectrometric (HPLC/MS) and HPLC/MS/MS analyses. The results showed the formation of eight main metabo