Comparative Metabolism of Furan in Rodent and Human Cryopreserved Hepatocytes
β Scribed by Gates, L. A.; Phillips, M. B.; Matter, B. A.; Peterson, L. A.
- Book ID
- 121861045
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- Year
- 2014
- Tongue
- English
- Weight
- 212 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0090-9556
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The UDS induction assay with primary hepatocytes as the target cells is a determinative assay for chemical carcinogens. This assay is, however, limited to the availability of freshly prepared liver cells. A cryopreservation technique for liver cells has recently been described. Frozen cells have bee
## Abstract Noncancerous adverse effects observed at the lowest dose for chloroacetanilide herbicides alachlor [2βchloroβ2β²,6β²βdiethylβ__N__β(methoxymethyl)βacetanilide] and acetochlor [2βchloroβ2β²βmethylβ6β²βethylβ__N__β(ethoxymethyl)acetanilide], but not metolachlor [2βchloroβ2β²βethylβ6β²βmethylβ__