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Comparative karyotype using bidirectional chromosome painting: how and why?

✍ Scribed by Marie-Noëlle Guilly; Laurent Dano; Patricia de Chamisso; Pierre Fouchet; Bernard Dutrillaux; Sylvie Chevillard

Book ID: 110319399
Publisher: Springer
Year: 2001
Tongue: English
Weight: 144 KB
Volume: 23
Category: Article
ISSN: 1573-0603
DOI: 10.1023/a:1013143010066

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The immortalized, nontumorigenic human breast epithelial cell line HMT-3522 has been used as a model for premalignant and, eventually, malignant development. During cultivation, the karyotype evolution was followed. At an early stage, a very long constant phase showed a near-diploid karyotype, with