Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments
✍ Scribed by V. Borsari; M. Fini; G. Giavaresi; M. Tschon; R. Chiesa; L. Chiusoli; A. Salito; L. Rimondini; R. Giardino
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 407 KB
- Volume
- 89A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 ± 8 μm and 53 ± 18 μm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 ± 7 μm and 36 ± 3 μm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen‐deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push‐out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 (p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA‐coated surfaces (p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA‐coated surfaces in trabecular bone (p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed (p < 0.05). Data showed that high roughness and Ti and HA‐coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009