Comparative HGH response to i.v. glucagon and i.v. arginine stimulation tests in children and adolescents

✍ Scribed by Z. Josefsberg; A. Pertzelan; Sh. Klonitzki-Peleg; R. Kauli; A. Silbergeld-Kowadlo; Z. Laron

• Book ID: 104776255
• Publisher: Springer
• Year: 1976
• Tongue: English
• Weight: 376 KB
• Volume: 121
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00443069

✦ Synopsis

Thirty-seven children and adolescents of several diagnostic entitites (constitutional growth retardation, diabetes mellitus and pituitary insufficiency) were tested with an i.v. bolus injection of ghicagon for plasma human growth hormone (HGH) response. Most of the subjects were also tested for the same purpose by the arginine stimulation test, and the data were compared.

It was found that i.v. ghieagon is a potent stimulus of human growth hormone release. The ttGH is released in two peaks, the first one occuring within 30 min, most probably by a direct effect. The second peak occurs after 120 rain, most probably as a secondary effect caused by the drop in blood glucose after its initial rise, which is induced by ghicagon. The peak concentrations of ttGH induced by glueagon, were very similar to those provoked by i.v. arginine in the same subjects.