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Comparative genomic hybridization study of primary neuroblastoma tumors

✍ Scribed by Maria Łastowska; Elizabeth Nacheva; Angela McGuckin; Ann Curtis; Colin Grace; Andrew Pearson; Nick Bown

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
757 KB
Volume
18
Category
Article
ISSN
1045-2257

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✦ Synopsis

Neuroblastoma tumors show a complex interaction of genetic abnormalities, among which some are of significant prognostic importance; however, analysis of chromosome changes in this tumor is often unsuccessful. Twenty primary tumors were studied by comparative genomic hybridization (CGH), and abnormalities were found in 19. While these changes included deletions of chromosome arm 1p (45%) and MYCN oncogene amplification (30%), gains of chromosome 17 material were much more frequent (75%). We also found evidence in two cases of a new amplification site at band 2p23.

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