Comparative Genomic Hybridization As a New Method for Detection of Genomic Imbalance
β Scribed by N. B. Ostroverkhova; S. A. Nazarenko; A. D. Cheremnykh
- Book ID
- 110328218
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2002
- Tongue
- English
- Weight
- 89 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1022-7954
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Comparative genomic hybridization (CGH) has become a widely used method in molecular cytogenetics to screen for copy number aberrations in human malignancies. Although the hybridization protocol is relatively simple, the validation and quality control of CGH have remained difficult. We describe here
## Abstract The genetic hallmark of retinoblastoma is mutation or deletion of the __RB1__ gene, whereas other genetic alterations that are also required are largely unknown. To screen for genomic imbalances on a genomewide level, we studied a series of 17 primary retinoblastomas by matrixβbased com