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Comparative genomic hybridization analysis of sporadic neuroendocrine tumors of the digestive system

✍ Scribed by Benoît Terris; Mounira Meddeb; Agnès Marchio; Gisèle Danglot; Jean-François Fléjou; Jacques Belghiti; Philippe Ruszniewski; Alain Bernheim

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
355 KB
Volume
22
Category
Article
ISSN
1045-2257

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✦ Synopsis

Little information is available on the molecular mechanisms underlying neuroendocrine tumorigenesis. To obtain an overview of the genomic imbalances characterizing these tumors, we studied 20 benign or malignant sporadic endocrine gastroenteropancreatic tumors by comparative genomic hybridization. Chromosomal imbalances were found in all tumors. Gains of chromosomal material were more frequent than losses. The most frequent gains were of chromosomes and chromosome arms 5 (55%), 14 (55%), 17q (55%), and 7 (50%). Losses were most frequent from 11q (30%) and 16p (30%). Gains of chromosome 5 did not occur in nonmetastatic tumors, whereas losses of 9p were observed exclusively in intestinal tumors. In addition, we found two high-level amplifications, of 17q11-21 and 19q13. A complementary FISH analysis revealed that the gain in 17q11-21 included amplification of the protooncogene HER2/neu. As in multiple endocrine neoplasia type-1-associated tumors, deletions of chromosome band 11q13 appear to be involved in the development of sporadic digestive tract neuroendocrine tumors, but our results suggest that other chromosomal regions are also involved.

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