Comparative evaluation of the diffusion of tobramycin and cefotaxime out of antibiotic-impregnated polymethylmethacrylate beads

✍ Scribed by Katharine J. Wilson; George Cierny; Kenneth R. Adams; Dr. Jon T. Mader

• Book ID: 102913812
• Publisher: Elsevier Science
• Year: 1988
• Tongue: English
• Weight: 736 KB
• Volume: 6
• Category: Article
• ISSN: 0736-0266
• DOI: 10.1002/jor.1100060216

✦ Synopsis

Both tobramycin and cefotaxime diffuse from antibiotic-impregnated polymethylmethacrylate (PMMA) beads in quantities sufficient to inhibit the growth of bacteria on agar lawns or in broth cultures over a 28-day period. Extraction of antibiotic from tobramycin or cefotaxime-impregnated PMMA beads revealed that substantial amounts of both antibiotics remained within the beads despite 28 days of diffusion. Diffusion of antibiotic from the PMMA beads during the initial 3-5 days is much greater than occurs for the remainder of the 4-week period. The results of the study suggest that perhaps tobramycin of cefotaxime-impregnated PMMA beads would produce local levels of antibiotic high enough to sterilize a given dead space for a period of 28 days.