✦ LIBER ✦

Comparative evaluation of the diagnostic performance of autofluorescence and diffuse reflectance in oral cancer detection: a clinical study

✍ Scribed by Jayaraj L. Jayanthi; Narayanan Subhash; Manju Stephen; Emmanuel K. Philip; Valappil T. Beena

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 867 KB
Volume: 4
Category: Article
ISSN: 1864-063X
DOI: 10.1002/jbio.201100037

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Autofluorescence (AF) and diffuse reflectance (DR) spectroscopic techniques have shown good diagnostic accuracies for noninvasive detection of oral cavity cancer. In the present study, AF and DR spectra recorded in vivo from the same set of sites in 65 patients were analyzed using Principal component analysis (PCA) and linear discriminant analysis (LDA). The effectiveness of these two techniques was assessed by comparison with gold standard and their discrimination efficiency was determined from the area under the receiver operator characteristic (AUC‐ROC) curve. Analysis using a DR technique shows a higher AUC‐ROC of 0.991 as against 0.987 for AF spectral data. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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