✦ LIBER ✦

Comparative efficacy of zolpidem and temazepam in transient insomnia

✍ Scribed by Milton K. Erman; Charles W. Erwin; Francis M. Gengo; Andrew O. Jamieson; Helio Lemmi; Mark W. Mahowald; Quentin R. Regestein; Thomas Roth; Barbara Roth-Schechter; Martin B. Scharf; Gerald W. Vogel; James K. Walsh; J. Catesby Ware

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 100 KB
Volume: 16
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.238

No coin nor oath required. For personal study only.

✦ Synopsis

This study compared hypnotic effects of zolpidem 10 mg, temazepam 15 mg and placebo in healthy adults. Two factors expected to promote insomnia, the 'first night effect' and a 2-hour phase advance, were combined in a single night laboratory-based double-blinded protocol. This was a multi-center study, with data collected in 13 sleep laboratories. Subjects with normal sleep histories and without prior sleep laboratory experience were randomly assigned to treatment groups. Medications were administered 15 min before lights out, with polysomnographic monitoring for 7.5 h. Subjective questionnaires and performance tests, digit symbol substitution test (DSST) and symbol copying test (SCT), were administered at study entry and after arising. 630 subjects completed the study and provided data analyzed using repeated measures ANOVAs. Neither agent significantly reduced objective sleep latency relative to placebo. Zolpidem reduced awakenings and wake after sleep onset (WASO); temazepam did not. Both agents improved sleep efficiency and most subjective sleep measures relative to placebo, with zolpidem superior for five of six subjective outcome measures compared to temazepam. SCT, morning sleepiness and morning concentration were not altered by any treatment. Zolpidem significantly reduced morning DSST performance; temazepam did not. Zolpidem 10 mg provided greater subjective hypnotic efficacy than temazepam 15 mg in this model of transient insomnia, with reduced polysomnographic awakenings and WASO. Impairment of DSST was seen with zolpidem but not temazepam. Copyright 2001 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Double-blind, placebo-controlled compari

Double-blind, placebo-controlled comparison of zolpidem, triazolam, and temazepam in elderly patients with insomnia

✍ Ilo E. Leppik; G. Barbara Roth-Schechter; G. William Gray; Martin A. Cohn; Dougl 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 2 views

Sleep disturbances and need for hypnotics are disproportionately greater in the elderly compared to younger adults. The present study provides a placebo-controlled subjective hypnotic efficacy of zolpidem, triazolam, and temazepam in elderly insomniacs. After a single-blind placebo screening week (D

Subjective hypnotic efficacy of trazodon

Subjective hypnotic efficacy of trazodone and zolpidem in DSMIII–R primary insomnia

✍ James K. Walsh; Milton Erman; C. W. Erwin; Andrew Jamieson; Mark Mahowald; Quent 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

Trazodone is an antidepressant which is used at low doses as a hypnotic. The hypnotic ecacy of trazodone in nondepressed insomniacs is unknown, especially in comparison to hypnotic medications such as zolpidem. Following a placebo screening week, DSM-IIIR de®ned primary insomniacs were randomized in

Adverse effects of temazepam in older ad

Adverse effects of temazepam in older adults with chronic insomnia

✍ Charles M. Morin; Celyne H. Bastien; Douglas Brink; Timothy R. Brown 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB

## Abstract ## Background Benzodiazepine‐hypnotics are frequently used for treating insomnia in older adults; however, there is little information about adverse effects associated with their usage over several weeks, particularly in this segment of the population. ## Objective This study reports

Use of zolpidem 10 mg as a benzodiazepin

Use of zolpidem 10 mg as a benzodiazepine substitute in 84 patients with insomnia

✍ H. Allain; F. Le Coz; P. Borderies; S. Schuck; B. de La Giclais; A. Patat; J. M. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

The antagonistic eects of zolpidem 10 mg on withdrawal symptoms caused by abrupt or gradual discontinuation (half-dose over 4 nights) of triazolam 0 . 25 mg in patients with chronic insomnia, who had been receiving regular treatment for over one month, were assessed in a randomized, double-blind, pl

Comparative efficacy of newer hypnotic d

Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis

✍ Yenal Dündar; Susanna Dodd; Judith Strobl; Angela Boland; Rumona Dickson; Tom Wa 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

## Abstract ## Objectives To compare the clinical effectiveness of zaleplon, zolpidem or zopiclone (Z‐drugs) with either benzodiazepines licensed and approved for use in the UK for the short‐term management of insomnia (diazepam, loprazolam, lorazepam, lormetazepam, nitrazepam, temazepam) or with

A randomized clinical trial comparing do

A randomized clinical trial comparing doses and efficacy of lormetazepam tablets or oral solution for insomnia in a general practice setting

✍ C. Ancolio; S. Tardieu; C. Soubrouillard; C. Alquier; V. Pradel; J. Micallef; O. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB

## Abstract Lormetazepam is a short‐acting benzodiazepine hypnotic which is beneficial in shortening the time to onset of sleep. The aim of the study was to assess a new formulation of lormetazepam (oral solution) in comparison with lormetazepam tablets in out‐patients with insomnia. This trial was