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Comparative effects of various lead salts on delayed hypersensitivity in mice

✍ Scribed by Jacques Descotes; Jean Claude Evreux; Alda Laschi-Locquerie; Pierre Tachon

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
131 KB
Volume
4
Category
Article
ISSN
0260-437X

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✦ Synopsis

Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell-mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.

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✍ H. K. Gill; F. Y. Liew πŸ“‚ Article πŸ“… 1978 πŸ› John Wiley and Sons 🌐 English βš– 498 KB

## Abstract A previous study (__Eur. J. Immunol.__ 1977. __7__: 714) has shown that mice injected intravenously (i.v.) with 1 Γ— 10^9^ sheep red blood cells (SRBC) produce cells which suppress delayed‐type hypersensitivity (DTH). These suppressor cells are Ξ˜β€positive, antigen‐specific and act via a