Comparative effects of endothelin (ET-1) and U46619 on human saphenous vein and gastroepiploic artery, sources of human autologous grafts

✍ Scribed by Dennis B. McNamara; Jerry T. Light; Robert K. Minkes; R. M. Saroyan; Peter Kvamme; Norman Rowe; Watts R. Webb; Lawrence Fox; Morris D. Kerstein; Noel L. Mills; Philip J. Kadowitz

• Book ID: 104674151
• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 345 KB
• Volume: 117
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00230413

✦ Synopsis

The effects of endothelin (ET-1) on smooth muscle contractile activity were investigated and compared in human saphenous vein and gastroepiploic artery, vessels frequently used in revascularization procedures. ET-1 contracted saphenous vein and gastroepiploic artery in a concentration-dependent manner. The peptide produced a greater maximal effect in the vein than in the artery and, in both preparations, ET-1 was less efficacious than U46619, an agent which mimics the actions of thromboxane A2 at the thromboxane A2/prostaglandin H2 receptor. The contractile response to ET-1 declined spontaneously at a more rapid rate in the artery than in the vein. The present data indicate that ET-1 has significant contractile activity in both vessels which are used for coronary arterial bypass surgery and suggest that although, a weaker vasoconstrictor than U46619, the peptide could induce vasospasm in both graft vessels.