## Abstract We studied the restoration of doxorubicin accumulation and sensitivity by verapamil and quinine in a variant of the human erythroleukemia cell line K562 selected for resistance to doxorubicin and presenting a multidrug‐resistance (MDR) phenotype. Verapamil was able to completely restore
✦ LIBER ✦
Comparative effects of doxorubicin and 4′-epi-doxorubicin on nucleic acid metabolism and cytotoxicity in a human tumor cell line
✍ Scribed by Orazio Cantoni; Piero Sestili; Flaminio Cattabeni; Cristina Geroni; Fernando Giuliani
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 511 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0344-5704
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The cytotoxicity of Doxorubicin and cis-dichloro-diammineplatinum (DDP) was evaluated in clones, obtained from a human ovarian cancer cell line transfected with a ternperaturesensitive p53 mutant, which express mutant p53 at 37°C and wild-type-like p53 at 32°C. DDP was equally active in cells not ex