Comparative effects of DL-glyceraldehyde, 6-mercaptopurine, methotrexate and 5-fluorouracil on the ehrlich ascites carcinoma in vivo

✍ Scribed by Leslie R. Bennett; Frank E. Connon

• Publisher: John Wiley and Sons
• Year: 1966
• Tongue: French
• Weight: 336 KB
• Volume: 1
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910010308

✦ Synopsis

Female white Swiss mice bearing the Ehrlich ascites carcinoma were treated with 6-mercaptopurine, methotrexate, 5-jluorouracil and DL-glyceraldehyde, alone and in combination, DL-glyceraldehyde was more effective against Ehrlich ascites tumor, as judged by 30-day post-inoculation survival time, than any of the three compounds with which it was compared. Combination of glyceraldehyde and 5-jluorouracil resulted in a slight potentiation of carcinostatic efect. DL-glyceraldehyde at carcinostatic dose levels was shown to have little toxic effect when administered for several days to white Swiss control mice.