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Comparative Effects of Chronic Haloperidol and Sulpiride Treatment on Nigral and Striatal GABA Content

✍ Scribed by Ferdinando Nicoletti; Francesco Patti; Daniele Filippo Condorelil; Liborio Rampello; Giovanni Giammona; Rosa-Maria Di Giorgio; Pier Luigi Canonico; Umberto Scapagnini


Book ID
111171568
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
348 KB
Volume
37
Category
Article
ISSN
0022-3042

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The ability of locally-administered AMPA and D1 receptor ligands to modulate in vivo striatal and nigral GABA efflux was determined in awake, intact male rats using a dual-probe microdialysis technique. Intrastriatal perfusion of AMPA (100 Β΅M) produced a 50-100% increase in striatal GABA efflux that