Comparative effectiveness of cathartics used with activated charcoal

✍ Scribed by EP Krenzelok; R Keller; RD Stewart

• Book ID: 104313309
• Publisher: Elsevier Science
• Year: 1985
• Tongue: English
• Weight: 279 KB
• Volume: 14
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(85)80379-6

✦ Synopsis

significant difference between the two groups in pH prior to CPR (6.99 vs 7.06 at -5; 6.97 vs 7.20 at -1). There were, however, statistically significant differences in pH in these two groups throughout CPR. The pH in Grp 2 was initially alkalotic (7.65 at +3 min), but it then approached the physiologic range and remained there until 30 min postarrest, when acidosis was noted (pH, 7.24). This is in sharp contrast to Grp 0, in which acidosis was present from the onset of resuscitation and worsened throughout (pH, 7.20 at +3; 6.80 at +40). In this model, the current regimen of 2 mEq/kg of NaHCO3 initially, followed by subsequent 1-mEq/kg doses, may not be optimal because it produces an initial alkalosis. A dosage schedule of 1 mEq/kg initially and subsequently might correct the acidosis without causing an initial alkalosis, and it might maintain pH in the physiologic range.