Comparative effect of local radiotherapy and surgery on cell-mediated immunity against a mouse transplantable mammary tumor
✍ Scribed by D. Le François; G. Duran Troise; N. Chavaudra; E. P. Malaise; G. Barski
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 734 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The specific anti‐tumor cell‐mediated immunity was investigated in mice bearing syngeneic transplantable tumors and submitted to local X‐irradiation. For this purpose, in vitro tests evaluating the immunologically specific inhibitory effect of lymphoid cells on target tumor cells were performed. The use of lymphoid cells obtained by peritoneal washings permitted us to follow the evolution of the immune status in the same mice during and after the treatment. At the same time when the non‐treated tumor‐bearing controls were immunologically inactive, being in an immunological “eclipse” phase, a significant reactivation of cellular immunity could be detected in a parallel series of mice, submitted to X‐ray treatment, as soon as the tumors began to decrease in size. This activity could still be detected more than 2 months after complete remission of the tumors. If a decrease in this immunity was observed, it was always premonitory of tumor recurrences and the immunological status of the relapsing animals became comparable to that of the tumor‐bearing non‐treated controls. The results obtained were very similar whether the whole population of peritoneal cells or only the “non‐adhering” fraction of it was used for in vitro tests. However, in the latter case, the immunological reactivation following X‐ray treatment appeared to begin earlier and to last longer. When compared with the surgically treated animals, the mice cured by X‐rays showed an earlier immunological reactivation. This reactivation, once it occurred, lasted in both cases for a comparable period after the total elimination of the tumors.