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Comparative distribution on niobium-95 in maternal and fetal rats and rabbits

✍ Scribed by M. Schneidereit; H. Kriegel

Book ID
105413060
Publisher
Springer
Year
1986
Tongue
English
Weight
240 KB
Volume
42
Category
Article
ISSN
1420-682X

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Maternal and fetal distribution of a pho
Maternal and fetal distribution of a phosphorothioate oligonucleotide in rats after intravenous infusion
✍ Nicole V. Soucy; Jason P. Riley; Michael V. Templin; Richard Geary; Ann de Peyst πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 137 KB

## Abstract **BACKGROUND:** Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20‐base phosphorothioate oligonucleotide, in timed‐pregnant Sprague‐Dawley rats. **METHODS:** To maximize the potential for fetal exposure, ISIS 2105 was administer