## Abstract Seventeen monoclonal antibodies are currently approved in the United States for therapeutic use in organ transplantation, percutaneous coronary intervention, prophylaxis of respiratory syncytial virus disease, rheumatoid arthritis, Crohn's disease, asthma, chronic lymphocytic leukemia,
Comparative clinical pharmacology of [111In]-labeled murine monoclonal antibodies
β Scribed by M. G. Rosenblum; J. L. Murray; L. Lamki; G. David; D. Carlo
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 694 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Conjugates of the chelating agents DTPA and TTHA with a monoclonal anti-HCG were prepared. The tissue distribution of the 111In-labeled conjugates and also 111In-citrate was studied in mice bearing human choriocarcinoma xenografts. The antibody conjugates both gave high liver and spleen radionuclide
Monoclonal antibody 3E1.2 was coupled with the bifunctional chelate, cyclic DTPA anhydride, at molar ratios (cOTPAA:3E1.2) of 1:1, lO:l, 1OO:l and 1oOO:l. The desired substitution level of less than one mol of D"PA/bl of 3E1.2 was achieved at a molar ratio of 1O:l and a coupling efficiency of 9.9t3.