Comparative chronic toxicity, including tumorigenicity, of gallium arsenide and arsenic trioxide intratracheally instilled into hamsters
✍ Scribed by MD Shiro Ohyama; Noburu Ishinishi; Akira Hisanaga; Akiyo Yamamoto
- Book ID
- 101571570
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 493 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0268-2605
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✦ Synopsis
Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs) and arsenic trioxide (As203) were studied using Syrian golden hamsters given intermittent intratracheal instillations. GaAs particles (0.25 mg x 15 timedanimal) were likely to produce relatively severe lung damage and the survival of the animals was shortened significantly compared with a control group. The tumor incidence of each group examined was GaAs (3.3%), As,O, (3.3%) respectively, at a dose of 3.75 mg total metal given during 15 weeks. In this experiment, both arsenic trioxide and gallium arsenide had no apparent carcinogenicity or tumorigenicity.