Comparative chemical and biological analysis of coal tar-based therapeutic agents to other coal-derived materials
✍ Scribed by Cherylyn W. Wright; Douglas W. Later; Richard A. Pelroy; D. Dennis Mahlum; Bary W. Wilson
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 721 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
coal tar; coal tar therapeutic agents; gas chromatography-mass spectrometry; initiation/promotion mouse skin painting; microbial mutagenicity ; nitrogencontaining polycyclic aromatic compounds; polycyclic aromatic hydrocarbons.
In this study, methodologies developed for the analysis of synthetic fuel products were applied to the coal tar fractions isolated from coal tar-based pharmaceutical products. A pharmaceutical stock solution of 20% coal tar in alcohol, a 50% coal tar bath emulsion and a 4.3% coal tar shampoo were studied. The toxicology and chemical composition of the coal tar fractions isolated from these materials were compared with an industrial coal tar and with a direct-liquefaction coal liquid product. The coal tars and coal liquid product were fractionated into chemical classes by alumina column chromatography and individual components were identified and quantitated by high-resolution gas chromatography. The microbial mutagenicity of these materials was measured against S. typhimurium, TA 98. In addition, the industrial coal tar, coal-liquid product, and coal tar isolate from the 20% coal tar in alcohol solution were tested for initiating activity in an initiation/promotion mouse skin painting assay for carcinogenicity. The chemical compositions of the coal tar-based therapeutic agents, the industrial coal tar and direct-liquefaction coal liquid were similar. With the exception of the 50% bath emulsion, the microbial mutagenicity and tumor-initiating activity in mouse skin for those materials tested were also similar.
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