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Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

✍ Scribed by George Perry; Marta A. Taddeo; Akihiko Nunomura; Xiongwei Zhu; Tania Zenteno-Savin; Kelly L. Drew; Shun Shimohama; Jesús Avila; Rudolph J. Castellani; Mark A. Smith


Book ID
117794395
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
308 KB
Volume
133
Category
Article
ISSN
1532-0456

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Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mecha