Comparative biodistribution of thin-coated iron oxide nanoparticles TCION: Effect of different bisphosphonate coatings

✍ Scribed by David Portet; Benoît Denizot; Elmar Rump; François Hindre; Jean-Jacques Le Jeune; Pierre Jallet

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 221 KB
• Volume: 54
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.10027

✦ Synopsis

Abstract

Because the nature of their coatings influences the biodistribution of nanocolloids, five different bisphosphonates bearing OH, NH~2~, NMe~2~, and N+Me~3~ groups were evaluated in vivo. ^59^Fe‐labeled iron cores were coated by the different molecules and tested by intravenous injection to healthy adult male Wistar rats. The initial phase was estimated with ^59^Fe‐ and ^99m^Tc‐labeled nanoparticles biodistribution. The different coatings do not change hydrodynamic radius (∼12 nm) and relaxivities. The negative surface charge is half for particles coated with bisphosphonates bearing quaternary ammonium compared to those bearing a hydroxyl function. Nanoparticle vascular initial half disappearance time range between 25 and 39 min, with hepatic capture between 50 and 80% ID at 18 h. Bones and muscles fix globally around 35 % ID at 18 h, with high concentrations in the mineral bones. Hydroxy‐bisphosphonates and quaternary ammonium‐bisphosphonate‐coated nanoparticles are the most efficient for blood remanence, weak liver capture, and bone targeting. Drug Dev. Res. 54:173–181, 2001. © 2002 Wiley‐Liss, Inc.