Comparative biochemistry and pharmacology of salivary gland secretions : II. Chromatographic separation of the basic proteins from some North American rattlesnake venoms

✍ Scribed by Carlos A. Bonilla; M.Katie Fiero

• Publisher: Elsevier Science
• Year: 1971
• Tongue: English
• Weight: 882 KB
• Volume: 56
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)97807-5

✦ Synopsis

The highly basic proteins from three North American rattlesnake venoms have been isolated by a simple combination of Bio-Gel P-2 recycling adsorption chromatography and ion exchange on carboxymethyl-cellulose.

These basic proteins constitute less than 10% of the total protein in the crude venoms and are characterized by having small molecular weights, isoelectric points above N pH 1o.S and pharmacological activities (igz vZ:vo and igz v&o) resembling those of crotamine, the neurotoxin from

Crotalus dzcrrislts terri$cus,

the South American tropical rattlesnake.

l To whom reprint rcqucsts shoulcl bc clircctccl.

20 I?. 12.