Comparative bioavailability of S-carboxymethylcysteine from two dosage forms: Hard gelatin capsule and syrup

✍ Scribed by J-M. Aiache; J. P. Borel; J-P. Kantelip

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 292 KB
• Volume: 3
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510030310

✦ Synopsis

Abstract

Measurement of plasma concentrations after the oral administration of S‐carboxymethylcysteine in two different dosage forms, as a hard gelatin capsule and as a syrup, shows its relative bioavailability from the two formulations to be similar. With the exception of the time required to reach peak concentration, which shows a slight variation attributable to the time taken for the drug to be released from the capsule and to dissolve, parameters such as peak concentration, biological half‐life and area under the serum‐concentration curve whether from t=0 to t = 8h or from t = 0 to t=∞, are not statistically different. The areas under the plasma‐concentration curves between t = 0 and t = 8 h and between t = 0 and t = ∞ shows that for a confidence limit of 95 per cent, the mean for the capsular form does not differ by more than 3.3–10.3 per cent from the mean for the syrup.