COMPARATIVE BIOAVAILABILITY OF LETROZOLE UNDER FED AND FASTING CONDITIONS IN 12 HEALTHY SUBJECTS AFTER A 2·5 MG SINGLE ORAL ADMINISTRATION
✍ Scribed by A. SIOUFI; N. SANDRENAN; J. GODBILLON; P. TRUNET; C. CZENDLIK; H. HOWALD; Ch. PFISTER; F. EZZET
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 149 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0142-2782
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✦ Synopsis
Letrozole is a new non-steroidal inhibitor of the aromatase enzyme system. It is currently under development for the treatment of postmenopausal women with advanced breast cancer. To investigate the in¯uence of food on the bioavailability of letrozole, 12 healthy male volunteers were treated under fed and fasted conditions with single oral doses of 2´5 mg letrozole in ®lm-coated tablets. Plasma concentration pro®les were determined. No signi®cant dierence in the extent of absorption (AUC or AUC 0±8 h ) was observed between the two treatments but the rate of letrozole absorption decreased slightly under fed conditions. However, in view of the half-life of about 2 d this small change in the absorption rate is not considered to be of clinical relevance for treatment with repeated administrations. &1997 by John Wiley & Sons, Ltd.