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Comparative activity of idarubicin and idarubicinol in combination with cyclosporin A in multidrug-resistant leukemia cells

โœ Scribed by M. Tolomeo; Rosa Alba Gancitano; Maurizio Musso; Ferdinando Porretto; Rosanna Perricone; Vincenzo Abbadessa; Aurelio Cajozzo


Book ID
105994125
Publisher
Springer
Year
1996
Tongue
English
Weight
213 KB
Volume
39
Category
Article
ISSN
0344-5704

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๐Ÿ“œ SIMILAR VOLUMES


Reversal activity of cyclosporin A and i
โœ Giuseppe Toffoli; Giuseppe Corona; Roberto Sorio; Antonella Bertola; Mauro Boioc ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 198 KB

Cyclosporin A (CSA) is an effective inhibitor of the Pglycoprotein (P-gp) activity and has been shown to modulate multidrug resistance (MDR) in in vitro experimental models. During degradation of CSA, the metabolites arising from the parental compound reach high levels in the serum of patients, and