COMPARATIVE ABSORPTION OF BISMUTH IN SPRAGUE–DAWLEY RATS FOLLOWING ORAL ADMINISTRATION OF PREPARATIONS CONTAINING BISMUTH SUCROSE OCTASULFATE, BISMUTH SUBSALICYLATE, AND BISMUTH SUBCITRATE

✍ Scribed by NIRANJAN RAO; PAUL W. BROWN; PHYLLIS YERINO; JIM CHANG; KIN-KAI HWANG

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 433 KB
• Volume: 18
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/(sici)1099-081x(199701)18:1<1::aid-bdd996>3.0.co;2-0

✦ Synopsis

The absorption of bismuth from De-Nol (bismuth subcitrate, DN), Pepto-Bismol (bismuth subsalicylate, PB) and bismuth sucrose octasulfate (BISOS) was examined in male Sprague±Dawley rats after a single oral dose of each compound (60 mg bismuth). Bismuth was analysed in blood, urine, kidney, brain, liver, and lung using graphite furnace atomic absorption spectrophotometry. Bismuth C max averaged 18´4+11´6 ng mL 71 for BISOS, 292+130 ng mL 71 for DN, and 21´5+9´63 ng mL 71 for PB. C max was signi®cantly lower for BISOS compared to DN (p50´05) but not signi®cantly dierent for BISOS compared to PB (p40´05). Bismuth AUC was 1356+474 ng h 71 mL 71 for BISOS, 2129+452 ng h 71 mL 71 for DN, and 1824+919 ng h 71 mL 71 for PB, which indicated a lower extent of absorption from BISOS compared to DN. Kidney, liver, and lung levels of bismuth were also signi®cantly lower for BISOS compared to DN (p50´05). Bismuth urinary excretion was signi®cantly lower for BISOS (0´04+0´02%) compared to DN (0´27+0´15%) but not signi®cantly dierent compared to PB (0´07+0´03%). These data suggest that the absorption of bismuth following oral administration of bismuth sucrose octasulfate is signi®cantly lower than that from De-Nol and similar to that from Pepto-Bismol.