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Community-acquired non-A, non-B hepatitis: Clinical characteristics and chronicity

✍ Scribed by Richard E. Sampliner; Daniel I. Woronow; Miriam J. Alter; Linda A. Smallwood; Edward Tabor; Friedrich Deinhardt; Michael Roggendorf; Robert J. Gerety

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 383 KB
Volume: 13
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890130203

No coin nor oath required. For personal study only.

✦ Synopsis

The characteristics of 86 patients with acute non-A, non-B hepatitis were compared to 23 patients with acute hepatitis A and 76 with acute hepatitis B by medical record reviews of patients seen at 5 hospitals in Baltimore, Maryland, as part of case-control study of viral hepatitis. Results of serum aminotransferase levels, bilirubin, albumin, and prothrombin times alone could not distinguish the type of viral hepatitis because of extensive overlap. The alanine aminotransferase range for non-A, non-B hepatitis was 56 to 1819 IU/liters, for hepatitis A 250 to 1995 IU/liters, and for hepatitis B 203 to 2120 IU/liters. The ranges of aspartate aminotransferase and bilirubin for the types of hepatitis also overlapped. Fewer patients with non-A, non-B hepatitis or hepatitis A had a prolonged prothrombin time compared to patients with hepatitis B. Hepatic encephalopathy was seen only in two patients with hepatitis B. Forty-two percent of non-A, non-B hepatitis patients followed for 6 months or longer continued to have elevated alanine aminotransferase levels. Chronic alanine aminotransferase elevation was independent of the source of infection: transfusion, parenteral drug use, or all other sources. Prolonged follow-up is necessary to evaluate chronicity in patients with non-A, non-B hepatitis.

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