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Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

✍ Scribed by Capasso, Mario; Devoto, Marcella; Hou, Cuiping; Asgharzadeh, Shahab; Glessner, Joseph T; Attiyeh, Edward F; Mosse, Yael P; Kim, Cecilia; Diskin, Sharon J; Cole, Kristina A

Book ID: 109914447
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 388 KB
Volume: 41
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng.374

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## Abstract Germline mutations in the tumor suppressor gene __TP53__ are associated with high incidence of early‐onset malignancies, and somatic mutations occur in 20–40% of all breast cancer cases. We investigated the association of common genetic variation in __TP53__ and its flanking genes, __WD