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Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions

โœ Scribed by Lantinga-van Leeuwen, Irma S; Leonhard, Wouter N; Dauwerse, Hans; Baelde, Hans J; van Oost, Bernard A; Breuning, Martijn H; Peters, Dorien J M


Book ID
110026196
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
166 KB
Volume
13
Category
Article
ISSN
1018-4813

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Since identification of the genes mutated in patients with Autosomal Dominant Polycystic Kidney Disease, PKD1 and PKD2, a large number of different germ line mutations in both genes have been found by conventional PCR-based mutation detection methods. Nevertheless, in approximately 40% of the PKD1 f